Principal Scientist, Engineered Cell Therapy Discovery
Core
Leading discovery and optimization of engineered CAR T and eTCR T cell therapeutics for cancer and chronic diseases.
Role type
Principal Scientist, Engineered Cell Therapy Discovery
Builds
Next-generation engineered cell-based therapies for hematologic malignancies, solid cancers, and autoimmune disease
Domain
Biopharma / Cell Therapy / Immunology
Deliverable
production ML models | product features | research
Required skills
Immunology, Cell therapy, Logic-gated CAR T/eTCR circuit design, Gene delivery (lentiviral, retroviral, AAV), In vitro functional screening (cytotoxicity, cytokine production, proliferation), In vivo xenograft studies, Multidisciplinary team leadership, IND-enabling study reporting, Patent applications
Preferred skills
Postdoctoral research experience, Multi-color flow cytometry, Molecular biology (cloning, library generation), AI in scientific discovery, CRISPR screens, HT imaging
Technologies
Lentivirus, Retrovirus, AAV, CRISPR, Flow cytometry, Gibson Assembly, Golden Gate
Responsibilities
Set strategic direction for research programs, Lead in vitro functional screening of T cell therapies, Design and optimize genetic constructs and gene delivery approaches, Mentor junior scientists, Translate in vitro data to in vivo xenograft studies, Drive go/no-go decision-making, Contribute to IND-enabling reports and patents
Seniority
Principal, hands-on IC with strategy & mentorship
