Senior/Principal Scientist, Analytical Cell Line Engineering and Bioassay Development
Core
Design, generate, characterize, and manage stable mammalian analytical cell lines and develop cell-based bioassays to support potency and functional characterization of biologics.
Role type
Senior/Principal Scientist, Analytical Cell Line Engineering and Bioassay Development
Builds
Potency assays, functional characterization tools, and analytical control strategies for biologics
Domain
Biopharmaceuticals / Biologics Development
Required skills
stable mammalian cell line engineering, vector design, transfection/transduction, clonal isolation, genomic characterization, copy number analysis, flow cytometry, assay development, regulatory documentation, technical mentoring
Preferred skills
qPCR, ddPCR, sequencing, cell imaging, luminescence/fluorescence detection, high-throughput clone screening, CMC source documentation
Technologies
flow cytometry, qPCR, ddPCR, sequencing, cell imaging, luminescence, fluorescence
Responsibilities
Lead design and lifecycle management of analytical cell lines; develop cell-based potency and functional assays; translate mechanism of action into assay strategies; author regulatory documentation; mentor junior scientists; lead technical transfers
Seniority
Senior (3+ years post-PhD) / Principal (7+ years post-PhD), Individual Contributor Technical Leadership