Principal Associate Scientist, Biology
Core
Developing cell-based assays and target engagement strategies for oncology discovery programs to characterize novel therapeutic candidates.
Role type
Principal Associate Scientist (Cellular Biochemistry & Assay Development)
Builds
Screening cascades, target engagement strategies, and mechanism of action understanding for Helicon-based oncology programs.
Domain
Biopharmaceuticals / Oncology Drug Discovery
Deliverable
production ML models | product features | dashboards & analysis | research | client delivery | infrastructure | physical/clinical work
Required skills
Cell-based assay development (NanoBRET, HiBiT, AlphaLISA, HTRF), Molecular biology techniques (qPCR, Western blotting, immunoprecipitation, pulldown), Cell line engineering (CRISPR/Cas9, viral expression systems), Independent experimental design and execution, Data interpretation and discrepancy resolution
Preferred skills
Induced proximity or targeted protein degradation approaches, Oncology drug discovery experience
Technologies
NanoBRET, HiBiT, AlphaLISA, HTRF, CRISPR/Cas9
Responsibilities
Design and execute target engagement and mechanism-of-action studies, Develop cell-based assays from proof-of-concept to validated implementation, Perform and interpret supporting molecular assays, Independently manage experimental workflows and drive projects to completion, Provide technical mentorship to team members, Maintain high standards of data integrity and reproducibility
Seniority
Senior, hands-on IC
