Senior Associate Scientist, Oncology
Core
Design and execute protein conjugation experiments with oligonucleotide or small molecule payloads to support RNAi therapeutics against cancer.
Role type
Senior Associate Scientist (bioconjugation chemistry)
Builds
Novel protein conjugates for in vitro and in vivo oncology experiments
Domain
Oncology / RNAi therapeutics / Bioconjugation chemistry
Deliverable
production ML models | product features | dashboards & analysis | research | client delivery | infrastructure | physical/clinical work
Required skills
protein conjugation chemistry, biorthogonal chemistry, purification methods (FPLC, HPLC, TFF), oligonucleotide synthesis, synthetic chemistry lab techniques, instrumentation (LC-MS, UV-Vis), automation/plate-based protocols
Preferred skills
antibody-oligonucleotide conjugates experience, automation/plate-based protocols for high throughput, Benchling ELN experience
Technologies
FPLC, HPLC (IEX, SEC, RP), TFF, LC-MS, UV-Vis spectrometry, Benchling
Responsibilities
Plan and carry out protein conjugation experiments; Develop purification methods for novel protein conjugates; Design, synthesize, and purify modified oligonucleotides; Develop automation protocols for high throughput generation; Troubleshoot synthetic and process challenges; Maintain laboratory infrastructure and equipment; Document protocols and experimental data
Seniority
Senior, hands-on IC