Senior Associate Scientist, Ligand Discovery
Core
Design and execute ligand selection campaigns to expand RNAi delivery to all tissues, characterizing ligand-receptor interactions and evaluating ligands for tissue-specific delivery.
Role type
Senior Associate Scientist (Ligand Discovery)
Builds
In vitro ligand selection campaigns, protein antigens, and tissue-specific RNAi delivery evaluations
Domain
Biopharma / RNAi therapeutics / Protein biochemistry
Deliverable
production ML models | product features | dashboards & analysis | research | client delivery | infrastructure | physical/clinical work
Required skills
sterile cell culture, ELISA, SPR/BLI, flow cytometry, PCR, cloning, plasmid purification, protein purification (affinity chromatography, SEC), library construction, hit sequence recovery
Preferred skills
protein assays (SDS-PAGE/Western blot, immunoprecipitation), NGS library prep, preparative scale protein purification
Technologies
phage display, yeast display, MACS, FACS, ELISA, BLI, SPR, flow cytometry, PCR, cloning, plasmid purification, affinity chromatography, SEC
Responsibilities
Design and execute ligand selection campaigns using display technologies; Characterize ligand-receptor interactions using biochemical techniques and cell-based assays; Support library construction and hit sequence recovery; Assist with preparation and characterization of soluble and membrane-embedded protein antigens; Evaluate ligands for tissue-specific RNAi delivery in vitro and in vivo
Seniority
Senior, hands-on IC