Staff / Senior Scientist, Bioconjugation Chemistry
Core
Designing and executing bioconjugation strategies for peptide and oligonucleotide components to enable single-molecule proteome sequencing.
Role type
Staff / Senior Scientist, Bioconjugation Chemistry
Builds
Single-molecule proteome sequencing assay components and reagents
Domain
Life sciences / Proteomics / Chemical Biology
Deliverable
production ML models | product features | dashboards & analysis | research | client delivery | infrastructure | physical/clinical work
Required skills
protein and peptide bioconjugation, site-specific amino acid sidechain chemistry, NHS-ester chemistry, maleimide chemistry, click chemistry (CuAAC, SPAAC, IEDDA), isothiocyanate coupling, Edman Chemistry, HPLC method development, LC-MS/MS analysis, UV/Vis spectroscopy, capillary electrophoresis (CE), solid-phase peptide synthesis (SPPS), native chemical ligation, oligonucleotide conjugation techniques, statistical experimental design
Preferred skills
scalable surface chemistry methods, photoredox/iridium-catalyzed C-terminal labeling, DOE-based experimental design, early-stage biotech experience
Technologies
HPLC, LC-MS/MS, NMR, CE, UV/Vis, FTIR, Confluence
Responsibilities
Screen and select conjugation chemistries for peptides and oligonucleotides; design bioconjugation workflows using specific chemistries; synthesize and purify peptide and oligonucleotide conjugates; characterize conjugation efficiency, purity, and stability; scale conjugate synthesis from R&D to prototype-grade supply; develop labeling strategies for amino acid sidechains; contribute to intellectual property development; maintain experimental documentation and SOPs
Seniority
Staff / Senior Scientist, hands-on IC