Scientist, Bioconjugation
Core
Design, synthesize, purify, and characterize novel bioconjugates (oligonucleotide-protein/antibody conjugates) to support therapeutic pipelines for neuromuscular diseases.
Role type
Scientist, Bioconjugation Chemistry
Builds
Novel bioconjugates and conjugation technologies for clinical and preclinical programs
Domain
Biotechnology / Protein Chemistry / Oligonucleotide Therapeutics
Deliverable
production ML models | product features | dashboards & analysis | research | client delivery | infrastructure | physical/clinical work
Required skills
bioconjugation chemistry, protein purification, oligonucleotide conjugation, linker chemistry, site-specific modification, HPLC/FPLC chromatography, LC-MS/UPLC characterization, protein chemistry, experimental design, data analysis
Preferred skills
antibody-drug conjugate (ADC) experience, antibody-oligonucleotide conjugate (AOC) experience
Technologies
HPLC, FPLC, size-exclusion chromatography, ion-exchange chromatography, affinity chromatography, LC-MS, UPLC, capillary electrophoresis, SDS-PAGE, UV-Vis spectroscopy, dynamic light scattering
Responsibilities
Design and conduct experiments to synthesize and optimize conjugation of oligonucleotides to proteins, peptides, and antibodies; Develop and evaluate novel conjugation strategies, linker technologies, and site-specific modification approaches; Purify and characterize bioconjugates using chromatographic, spectroscopic, and complementary analytical techniques; Analyze and interpret experimental data to guide molecular design, experimental strategy, and process optimization; Independently troubleshoot complex synthetic, purification, and analytical challenges; Collaborate with cross-functional teams to advance therapeutic candidates and achieve project milestones; Support the transfer of conjugation processes to development and manufacturing teams
Seniority
Mid-level Scientist (0-3 years industry experience with PhD or 8+ years with Master's)