Senior Scientist, Oligonucleotide Chemist
Core
Develop and optimize synthesis, deprotection, purification, and modification methods for oligonucleotides to enable new product introduction and manufacturing transfer.
Role type
Senior Scientist, Oligonucleotide Chemist
Builds
Custom and co-creation oligonucleotide products for genomic analysis and quality assurance applications
Domain
Life sciences, nucleic acid therapeutics, diagnostics
Deliverable
production ML models | product features | dashboards & analysis | research | client delivery | infrastructure | physical/clinical work
Required skills
Oligonucleotide synthesis and chemistry, Automated synthesizer operation, HPLC and mass spectrometry, Process optimization, GMP compliance, Technical documentation, Troubleshooting chemical processes
Preferred skills
Experience with MerMade, Dr Oligo, Shasta, K&A, OligoMaker, AKTA platforms, Nucleic acid therapeutics applications
Technologies
Automated synthesizers, HPLC, Mass spectrometry, AKTA
Responsibilities
Design and execute development projects for oligonucleotide synthesis and modification, Optimize purification methods for modified oligonucleotides, Perform analytical characterization of oligonucleotides, Troubleshoot synthesis and purification processes, Generate documentation for operations transfer, Present findings to stakeholders
Seniority
Senior, hands-on IC