Scientist II, Conjugation Development
Core
Lead experimental activities to develop and optimize the conjugation process for pneumococcal conjugate vaccines, focusing on preparing, purifying, and characterizing chemically modified polysaccharides and conjugates.
Role type
Scientist II, Conjugation Development
Builds
Pneumococcal conjugate vaccines for bacterial disease prevention
Domain
Biopharmaceuticals / Vaccine Development
Deliverable
production ML models | product features | dashboards & analysis | research | client delivery | infrastructure | physical/clinical work
Required skills
biochemistry, organic chemistry, protein-polysaccharide conjugate synthesis, tangential flow filtration, HPLC, SEC-MALS, analytical method development, experimental design, electronic lab notebooks
Preferred skills
Design of Experiments, chemical modification of polysaccharides
Technologies
HPLC, SEC-MALS, TFF, dialysis, size-exclusion chromatography
Responsibilities
Optimize and troubleshoot multi-step syntheses of protein-polysaccharide conjugates; Purify polysaccharides and conjugates using dialysis, size-exclusion chromatography, and tangential flow filtration; Analyze polysaccharides and conjugates with various analytical methods; Advise team members on experimental design and troubleshooting; Serve as a subject matter expert during tech transfer to contract manufacturing organizations; Maintain highly organized records for optimization and reproducibility assessment.
Seniority
Mid-level Scientist (2-5 years industry experience or equivalent)