Scientist, RNA Chemistry
Core
Develop Dyne's oligonucleotide chemistry platform and support the discovery of novel nucleic acid therapeutics for neuromuscular diseases.
Role type
RNA Chemistry Scientist
Builds
Modified RNA oligonucleotides (ASO, siRNAs) and antibody-oligonucleotide conjugates for in vitro and in vivo studies
Domain
Biotechnology / RNA therapeutics
Deliverable
production ML models | product features | dashboards & analysis | research | client delivery | infrastructure | physical/clinical work
Required skills
Modified RNA synthesis, oligonucleotide synthesis, HPLC, LCMS, anion exchange chromatography, reverse phase chromatography, IP/RP chromatography, IEX, SEC, melting temperature analysis, database management, ELN, hit-to-lead optimization, antibody-oligonucleotide conjugate preparation
Technologies
HPLC, LCMS, anion exchange, reverse phase, IP/RP, IEX, SEC
Responsibilities
Independently perform synthesis of modified RNA oligonucleotides incorporating diverse sugar and backbone chemistries; Troubleshoot and optimize synthesis methods to produce high quality oligonucleotides; Interpret analytical data to enable improved purity and yields; Carry out purification, analysis, and characterization of oligonucleotides and their conjugates; Register synthesized oligonucleotides in the database and report experiments in the ELN; Contribute to the design of oligonucleotides and perform hit-to-lead optimization; Generate intermediates to prepare antibody-oligonucleotide conjugates
Seniority
Mid-level, hands-on IC