Principal Scientist - RGM Chemistry
Core
Lead discovery, development, and optimization of antibody-oligonucleotide conjugation technologies for next-generation targeted therapeutics.
Role type
Principal Scientist (RGM Chemistry)
Builds
Scalable antibody-oligo conjugates and bioconjugation methods for preclinical supply
Domain
Biopharmaceuticals / Bioconjugation Chemistry / RNA Therapeutics
Deliverable
production ML models | product features | dashboards & analysis | research | client delivery | infrastructure | physical/clinical work
Required skills
Antibody-oligonucleotide conjugation expertise, bioconjugation science, oligonucleotide therapeutics knowledge, advanced analytical techniques (HPLC, LC-MS, bioassays), multidisciplinary team leadership, therapeutic candidate advancement
Preferred skills
Innovation in bioconjugation or RNA delivery, mentoring talent, cross-functional collaboration, strategic planning
Technologies
HPLC, LC-MS, bioassays
Responsibilities
Design experiments to refine linker chemistry, payload stability, and delivery efficiency; Analyze conjugates for purity, identity, and functional potency; Lead project stand-ups and mentor scientists; Partner with Process Development to scale conjugation methods; Scout and evaluate emerging bioconjugation technologies; Present program updates to senior R&D leadership
Seniority
Principal, strategy & mentorship