Principal Scientist, Research (Targeted Delivery)
Core
Lead ligand discovery projects for novel receptors to advance RNAi therapeutics into the future by opening up targeted delivery to all tissues.
Role type
Principal Scientist, Research (Antibody Discovery & Engineering)
Builds
Novel antibody modalities (multispecific antibodies, nanobodies) and ligand candidates for RNAi therapeutics.
Domain
Biopharmaceuticals / RNAi therapeutics / Immunology
Deliverable
production ML models | product features | dashboards & analysis | research | client delivery | infrastructure | physical/clinical work
Required skills
Antigen design, antibody engineering, immunology, high-throughput screening technologies, single B cell isolation, NGS library preparation and data interpretation, automated screening assay development, CRO management
Preferred skills
Leading antibody discovery programs from inception to lead candidate delivery, managing research scientists
Technologies
Bruker Beacon platform, Next-Generation Sequencing (NGS)
Responsibilities
Lead the design and implement innovative immunization strategies; Establish and oversee high-throughput B cell screening and selection workflows; Develop and integrate a robust Next-Generation Sequencing (NGS) workflow; Drive the design, execution, and automation of high-throughput screening cascades; Engineer complex antibody modalities, including Mult specific antibodies, nanobodies, and evaluate novel protein formats; Manage project timelines, resources, and data analysis, and present findings to internal teams and senior leadership.
Seniority
Principal, hands-on IC with strategy & mentorship
