Scientist, Chemistry
Core
Designing and optimizing antibody-drug conjugates (ADCs) through synthetic chemistry, bioconjugation, and analytical characterization to support preclinical drug discovery.
Role type
Senior IC medicinal chemist (ADC bioconjugation)
Builds
Novel ADC molecules and linker-payload combinations for preclinical in vitro and in vivo studies
Domain
Biopharmaceuticals / Antibody-Drug Conjugates
Deliverable
production ML models | product features | dashboards & analysis | research | client delivery | infrastructure | physical/clinical work
Required skills
ADC bioconjugation, site-specific conjugation, synthetic route design, purification (HPLC, SEC, HIC), analytical characterization (LC-MS, NMR), structure-activity relationship analysis
Preferred skills
None stated
Technologies
HPLC, SEC, HIC, LC-MS, NMR, SDS-PAGE, UV-Vis
Responsibilities
Perform bioconjugations of linker-payload combinations to antibodies; Develop and optimize novel antibody-drug conjugation strategies; Design, execute, and optimize synthetic routes to access target molecules; Select and apply purification techniques for small molecules and biologics; Acquire, analyze, and interpret analytical data; Use in silico tools to generate hypotheses and design target molecules
Seniority
Senior, hands-on IC
