Senior Scientist II – ADC Reaction Engineer
Core
Design and develop scalable manufacturing processes for drug substances and products, specifically focusing on antibody drug conjugates (ADCs), small molecules, and biologics from pre-clinical through clinical stages.
Role type
Senior IC chemical/bio-process engineer (ADC reaction & scale-up)
Builds
Robust manufacturing processes, flow chemistry reactor platforms, and commercial-ready production methods for therapeutics.
Domain
Pharmaceutical manufacturing / ADC development / Chemical Engineering
Deliverable
production ML models | product features | dashboards & analysis | research | client delivery | infrastructure | physical/clinical work
Required skills
modeling antibody drug conjugate kinetics and mechanisms, drug linker and drug substance process design, flow chemistry reactor platform development, highly potent compound handling, novel reactor configuration leadership (photochemistry, electrochemistry, membrane reactors), computational fluid dynamics expertise, reaction kinetics and transport phenomena modeling, mathematical modeling for scale-up, process analytical technology application, model-guided experimentation.
Preferred skills
leadership in cross-functional process development teams, scientific publication and conference presentation, strategic project planning in matrixed environments.
Technologies
flow chemistry reactor platforms, computational fluid dynamics tools, process analytical technologies, pilot plant equipment.
Responsibilities
Develop robust manufacturing processes supporting assets through all phases of development; lead project teams for characterization of new small and large molecule assets; establish and execute research plans; demonstrate processes in pilot plant; address challenging problems with chemical/biochemical reactions and separations; build data-driven models to facilitate scale-up and tech transfer; author technical documents for regulatory filings.
Seniority
Senior, hands-on IC with strategic project leadership
