Principal Scientist, Protein Design
Core
Lead technical execution of in vitro selection and cell-surface screening for viral and bacterial antigens to optimize glycoprotein candidates for mRNA medicines.
Role type
Principal Scientist, Protein Design (In Vitro Selection)
Builds
High-throughput mammalian cell-based screening platforms and scalable selection systems for vaccine antigens.
Domain
Biopharma / Protein Engineering / mRNA therapeutics
Deliverable
production ML models | product features | dashboards & analysis | research | client delivery | infrastructure | physical/clinical work
Required skills
in vitro selection, mammalian cell-surface display, directed evolution, high-throughput screening design, computational protein design workflows, experimental assay design, scientific leadership
Preferred skills
glycoprotein antigen engineering, library design and construction, NGS-based readouts, quantitative enrichment analysis
Technologies
mammalian display systems, NGS, DNA assembly
Responsibilities
Lead execution of in vitro selection and cell-surface screening campaigns; Design and run high-throughput mammalian display campaigns for complex glycoproteins; Build and deploy scalable screening systems replacing plate-based assays; Develop advanced in vitro selection and directed-evolution capabilities; Serve as experimental partner to computational design teams; Provide technical mentorship to junior scientists
Seniority
Principal, hands-on IC with strategic ownership