Principal/Senior Scientist, mRNA engineering
Core
Leading mRNA production and engineering efforts to synthesize, purify, and characterize mRNA at large scales for in vivo and in vitro studies.
Role type
Principal/Senior Scientist, mRNA engineering
Builds
High-quality mRNA batches for therapeutic development
Domain
Biotechnology / mRNA therapeutics / Epigenetic reprogramming
Deliverable
production ML models | product features | dashboards & analysis | research | client delivery | infrastructure | physical/clinical work
Required skills
IVT (in vitro transcription), TFF (tangential flow filtration), chromatography, mRNA QC assays, GLP compliance, SOP development, team mentorship
Preferred skills
Python/R for sequence analysis, LNP formulation knowledge, plasmid design, CMO management
Technologies
TFF systems, chromatography systems, direct RNA sequencing, fragment analysis
Responsibilities
Execute and scale end-to-end mRNA production (template prep, IVT, purification); Implement rigorous quality control assays; Author and maintain SOPs and batch records; Design experiments to improve mRNA potency and manufacturing performance; Train and mentor team members
Seniority
Senior, hands-on IC