Scientist I, De Novo Discovery and Screening
Core
Designing and executing phage and mRNA display high-throughput screening campaigns to discover novel binders against challenging protein targets for next-generation therapeutics.
Role type
Scientist I, Hit Discovery (Phage/mRNA Display)
Builds
Novel binder libraries and screening workflows for Helicon-based drug discovery programs
Domain
Biopharmaceuticals / Chemical Biology / Protein Engineering
Deliverable
production ML models | product features | dashboards & analysis | research | client delivery | infrastructure | physical/clinical work
Required skills
Molecular biology techniques (PCR, cloning, DNA/RNA handling), Library construction, High-throughput screening workflows, Display technologies (phage/mRNA), Next-generation sequencing data analysis, Experimental design and troubleshooting
Preferred skills
Laboratory automation, Noncanonical amino acid integration, Cross-functional collaboration
Technologies
Phage display, mRNA display, PCR, Cloning, In vitro transcription/translation, Next-generation sequencing
Responsibilities
Design and execute high-throughput screening campaigns, Construct and produce diverse display libraries, Perform display selections and hit characterization, Analyze sequencing data to guide decision-making, Optimize mRNA display platform workflows, Collaborate with data science and assay development teams
Seniority
Early-career Scientist (0-2 years postdoc/industry experience)