Senior Scientist: Bispecifics and Antibody Engineering
Core
Design, produce, and characterize next-generation multi-specific antibodies and protein therapeutics focusing on myeloid cell biology.
Role type
Senior Scientist, antibody engineering
Builds
Novel logic-gated alternative format antibodies and protein therapeutics
Domain
Biopharmaceuticals / Protein therapeutics / Myeloid cell biology
Deliverable
production ML models | product features
Required skills
Molecular biology, structural biology, antibody expression in mammalian cell lines, antibody purification (AKTA systems), protein characterization, high-throughput construct generation, vector engineering, biochemical and cell-based assay design (ELISA, AlphaLISA, flow cytometry), data analysis
Preferred skills
Cell-free expression, structural AI/ML-design
Technologies
AKTA systems, Benchling, research ELN
Responsibilities
Design innovative multi-specific antibodies with desired potency and selectivity; perform molecular and structural-guided design and high-throughput construct generation; produce and purify novel antibodies using mammalian expression systems; characterize binding affinities, kinetics, and stability; design and implement high-throughput biochemical and cell-based assays; troubleshoot bioanalytical and cell-based assay data; communicate biologic designs and data updates to program stakeholders.
Seniority
Senior, hands-on IC
