R&D - Intrepide-Principal Scientist I, Biologics Discovery & Innovation - SZ
Core
Lead global R&D projects for biologics discovery, engineering, and technology platforms in oncology, immunology, ophthalmology, or CNS, operating in internal–CRO hybrid models.
Role type
Principal Scientist, Biologics Discovery & Innovation
Builds
Therapeutic pipelines for biologics (antibodies, bispecifics, nanobodies) from concept to key milestones
Domain
Biopharmaceuticals / Biologics Discovery
Deliverable
production ML models | product features | dashboards & analysis | research | client delivery | infrastructure | physical/clinical work
Required skills
Antibody discovery program leadership, Antigen design and immunization strategy, Hit identification and lead selection, Display screening expertise (phage, yeast, ribosome, single B cell cloning), Bispecific/multispecific antibody discovery, CRO management and hybrid workflow execution, Antibody engineering (affinity maturation, humanization), AI-driven screening and machine learning-assisted design
Preferred skills
Nanobody/VHH discovery workflows, Managing complex multi-stakeholder global programs, Peer-reviewed publications and patents
Technologies
Phage display, Yeast display, Ribosome display, Single B cell cloning, Hybridoma technology, AI-based antigen design, Computational screening, Laboratory automation
Responsibilities
Oversee full arc of antibody programs from antigen design to lead selection, Design and execute antigen engineering strategies, Lead discovery campaigns for advanced modalities, Coordinate external CRO partnerships and define project scopes, Apply antibody engineering to advance discovery leads
Seniority
Principal, strategic execution and team leadership
