Senior Principal Scientist, Small Molecule Therapeutics
Core
Lead protein science and structural biology strategy to enable small molecule drug discovery through high-quality protein reagents and structural insights.
Role type
Senior Principal Scientist, Small Molecule Therapeutics
Builds
Protein reagents, structural biology workflows, and internal capabilities for screening and hit validation
Domain
Biopharmaceuticals / Structural Biology / Drug Discovery
Deliverable
production ML models | product features | dashboards & analysis | research | client delivery | infrastructure | physical/clinical work
Required skills
recombinant protein expression and purification, protein construct design and engineering, X-ray crystallography, Cryo-EM, CRO management, analytical biophysics, cross-functional program execution
Preferred skills
scaling internal protein science capabilities, challenging target classes (membrane proteins, GPCRs), AI/ML-enabled protein design, automation workflows
Technologies
X-ray crystallography, Cryo-EM, SEC-MALS, SPR, ITC, MST, DNA-encoded library screening
Responsibilities
Lead protein science strategy for small molecule programs, oversee recombinant protein expression and purification efforts, develop roadmap for in-house capabilities, lead construct design and protein engineering, manage external CROs for crystallography and Cryo-EM, establish quality-control expectations for protein reagents, troubleshoot protein production and structural biology challenges, mentor future team members
Seniority
Principal, strategy & mentorship
