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Principal Scientist, Computational Protein Design

Cambridge, Massachusetts💼 Full-time💰 $142,500–$142,500🗓 2026-03-02 → 2026-07-31

Core

Lead computational protein design for mRNA therapeutics, vaccines, and biologics, creating antigens, binders, and antibodies validated in vitro and in vivo.

Role type

Principal Scientist, Computational Protein Design

Builds

Novel mRNA vaccine candidates and biologics for clinical advancement

Domain

Biopharma / mRNA therapeutics / Computational Biology

Deliverable

production ML models | product features

Required skills

Structure-based protein and interface design, Deep learning for protein design, In vitro selection and screening interpretation, Design strategy and technical decision-making, Mentorship of junior designers, Library construction and mutational strategy

Preferred skills

Python programming, Rosetta, ProteinMPNN

Responsibilities

Own design strategy and technical decision-making for vaccine programs, Design antigens, binders, and antibodies, Partner with experimental teams to drive iterative design cycles, Provide guidance on library construction and hypothesis testing, Mentor junior designers, Contribute to cross-functional program strategy

Seniority

Principal, hands-on IC with mentorship

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