Scientist, ADC Oncology Discovery Biology
Core
Designing and executing experimental studies to advance antibody-drug-conjugate (ADC) oncology programs from target validation to lead optimization and IND-enabling activities.
Role type
Senior IC scientist (ADC discovery biology)
Builds
Novel ADC drug candidates and validated biological mechanisms for oncology therapeutics
Domain
Biopharmaceuticals / Oncology / Immuno-oncology
Deliverable
production ML models | product features | dashboards & analysis | research | client delivery | infrastructure | physical/clinical work
Required skills
ADC mechanism of action analysis, molecular and cellular study design, high-throughput cell-based assay development, flow cytometry, expression modulation tools (CRISPR, shRNA, siRNA), tissue culture, qPCR, western blot, ELISA, Luminex, DNA/RNA/protein processing
Preferred skills
Oncology and immuno-oncology biologics drug discovery experience, high content imaging platform expertise, 2D/3D co-culture activity assay design, project prioritization in matrixed organizations
Technologies
CRISPR, shRNA, siRNA, Incucyte, multi-parametric flow cytometry, ELISA, Luminex
Responsibilities
Design and execute molecular and cellular studies to establish PD/efficacy relationships; develop screening funnel assays for compound triaging; collaborate with informatics, translational research, and lead optimization teams; present data in lab and project meetings; conduct independent experimental work with detailed record-keeping.
Seniority
Senior, hands-on IC
