Senior Scientist I, Cell Line Development
Core
Designing and optimizing CHO cell line platforms to increase recombinant antibody titers for biologics manufacturing.
Role type
Senior Scientist I, Cell Line Development (Hands-on IC)
Builds
Stable CHO cell lines for recombinant antibody production
Domain
Biologics / CMC / Molecular Biology
Deliverable
production ML models | product features | dashboards & analysis | research | client delivery | infrastructure | physical/clinical work
Required skills
Vector construct design and testing, Aseptic mammalian cell culture, Transfection, CRISPR/Cas cell engineering, Flow cytometry, ddPCR / RT-qPCR, Octet (BLI), ViCell, Microfluidic clone-screening, Geneious Prime, Genomic and epigenetic regulation theory, mRNA stability analysis, Protein secretion machinery knowledge
Preferred skills
Industrial CMC experience, NGS library prep and analysis, Python/R programming, Multi-strategy expression engineering
Technologies
Geneious Prime, Octet, ViCell, CloneSelect Imager, Beacon, CRISPR/Cas
Responsibilities
Design and test dozens of vector constructs in stable CHO cell lines, Execute transfection and clone-generation campaigns, Operate and interpret data from core CLD instrumentation, Author technical reports and present data to leadership, Collaborate with cell culture, analytical, and bioinformatics teams
Seniority
Senior, hands-on IC
