Principal Scientist, Cell Pharmacology
Core
Design, develop, and implement innovative cell-based assays to screen and progress hits for Helicon™ peptide programs targeting intracellular proteins in oncology and other disease areas.
Role type
Principal Scientist, Cell Pharmacology (Hands-on IC with team leadership)
Builds
Early-stage Helicon™ peptide programs (alpha-helical peptides) for oncology and other solid tumor indications
Domain
Biopharmaceuticals / Oncology / Cell Biology / Peptide Drug Discovery
Deliverable
production ML models | product features | dashboards & analysis | research | client delivery | infrastructure | physical/clinical work
Required skills
Cell-based assay design and execution (HTRF, AlphaLISA, NanoBRET, HiBiT, MSD), High-throughput cellular screening, Multiparametric dataset analysis, Mammalian cell culture, CRISPR/RNAi-mediated gene modulation, Western blotting, qPCR, Flow cytometry, Immunofluorescence, High-content imaging, Data management (Dotmatics), Experimental documentation and data integration
Preferred skills
People management, Authorship on peer-reviewed publications or patents, AI tool proficiency
Technologies
HTRF, AlphaLISA, NanoBRET, HiBiT, MSD, Dotmatics, CRISPR, RNAi, Flow cytometry, High-content imaging platforms
Responsibilities
Lead development and optimization of high-throughput cellular and molecular assays; Serve as subject matter expert on target engagement and functional assays; Manage and mentor a small team executing cell-based assay development; Drive discovery of Helicons to inform structure-activity relationships; Lead LIMS initiative for biology data QC; Contribute to strategic planning of IND-enabling studies; Synthesize and communicate experimental findings to executive forums; Mentor junior scientists; Champion scientific innovation and evaluate emerging technologies
Seniority
Principal, hands-on IC with team leadership