Senior Scientist (Organic Chemist-Oligonucleotide Delivery)
Core
Designing and synthesizing novel delivery ligands, conjugation linkers, and nucleotides to chemically modify oligonucleotides for enhanced delivery and efficacy of RNA therapeutics.
Role type
Senior Organic Chemist (Oligonucleotide Delivery)
Builds
siRNA-based therapeutics and novel delivery mechanisms for the Genetic Medicines group
Domain
Biotechnology / RNA Therapeutics / Organic Synthesis
Deliverable
production ML models | product features | dashboards & analysis | research | client delivery | infrastructure | physical/clinical work
Required skills
small molecule synthesis, carbohydrate synthesis, oligonucleotide synthesis, ligand design, linker/spacer synthesis, purification strategies, analytical characterization, scalable workflow development
Preferred skills
hands-on laboratory experience with diverse synthetic compounds, cross-functional collaboration, state-of-the-art characterization techniques, independent research
Technologies
N/A
Responsibilities
Design and prepare novel delivery ligands, conjugation linkers, and nucleotides; Develop and optimize synthetic routes and purification strategies; Perform hands-on synthesis, isolation, and characterization of molecules at mg-to-gram scales; Synthesize oligonucleotides incorporating novel synthetic moieties; Develop scalable and reproducible workflows; Serve as a chemistry subject-matter expert in cross-functional meetings; Prepare research results for presentations, patent applications, and scientific publications
Seniority
Senior, hands-on IC