Senior Associate Scientist, LNP Formulations
Core
Develop and optimize Lipid Nanoparticle (LNP) formulations for mRNA and siRNA delivery, supporting in vitro/in vivo studies and R&D projects.
Role type
Senior Associate Scientist, LNP Formulations
Builds
LNP formulations encapsulating siRNAs and/or mRNAs for therapeutic applications
Domain
Biopharmaceuticals / Drug Delivery Systems
Deliverable
production ML models | product features | dashboards & analysis | research | client delivery | infrastructure | physical/clinical work
Required skills
LNP formulation (in-line mixing, TFF), physicochemical characterization (DLS, NTA, zeta potential, HPLC, UPLC, capillary electrophoresis), mRNA/siRNA encapsulation, QC analysis, high-throughput screening, antibody/peptide/small molecule formulation
Preferred skills
High-throughput formulation screening, antibody/peptide/small molecule formulation experience
Technologies
DLS, NTA, zeta potential, UV/fluorescence spectroscopy, HPLC, UPLC, ribogreen assay, capillary electrophoresis, gel electrophoresis
Responsibilities
Conduct LNP formulation optimization and characterization; Support in vitro/in vivo studies by producing LNPs; Generate analytical data to understand physicochemical parameters; Support novel method development of LNP characterization; Design, plan and perform scientific experiments; Analyze and present experimental data; Maintain electronic lab notebook and SOPs
Seniority
Mid-level (2-4 years experience), hands-on IC