Senior Scientist (Oligonucleotide Conjugation)
Core
Designing, synthesizing, purifying, and analytically characterizing oligonucleotide conjugates (protein-oligonucleotide, small molecule-oligonucleotide, peptide-oligonucleotide) to support siRNA-based therapeutics.
Role type
Senior Scientist (Oligonucleotide Conjugation)
Builds
Pre-clinical oligonucleotide conjugates for siRNA therapeutics
Domain
Biotechnology / Oligonucleotide Chemistry
Deliverable
production ML models | product features | dashboards & analysis | research | client delivery | infrastructure | physical/clinical work
Required skills
Oligonucleotide conjugation chemistry, Synthesis of oligo conjugates (small molecules, linkers, peptides, proteins), Analytical characterization, Protocol optimization, Biophysical/biochemical assay design and execution, Electronic lab notebook management
Preferred skills
Site-specific bioconjugation techniques, RNA therapeutic modalities (ASO, siRNA), Preparative and analytical chromatography (IEX, RP-HPLC, SEC, LC-MS), Automated oligonucleotide synthesizers
Technologies
IEX, RP-HPLC, SEC, LC-MS, ELISA, SPR, FRET, BLI, DSF, DLS
Responsibilities
Designing, synthesizing, purifying, and analytically characterizing oligonucleotide conjugates; Optimizing synthesis/conjugation/purification protocols; Performing hands-on conjugate synthesis; Collaborating with cross-functional teams to meet project objectives; Preparing research results for presentations, patent applications, and scientific publications; Conducting biophysical/biochemical assays to evaluate target binding, stability, and conjugate properties
Seniority
Senior, hands-on IC