Oligo Discovery Chemistry Principal Scientist
Core
Establish pre-clinical oligonucleotide conjugation capabilities and develop synthetic workflows for ASOs, siRNA, SSO, and RNA editors.
Role type
Principal Scientist, Oligo Discovery Chemistry
Builds
Small molecules, lipids, linkers, and conjugates for next-generation oligonucleotide therapeutics.
Domain
Biopharmaceuticals / Oligonucleotide Therapeutics
Deliverable
production ML models | product features | dashboards & analysis | research | client delivery | infrastructure | physical/clinical work
Required skills
Multistep synthesis (milligram to gram scale), Structure-Activity Relationship (SAR) studies, SOP development, HPLC purification (reverse phase, size exclusion, ionic chromatography), LC/MS analytics, Lipid/PEG-lipid/sterol chemistry, Amidite synthesis, RNA therapeutics familiarity
Preferred skills
Nucleoside chemistry, Oligonucleotide synthesis
Technologies
Agilent, Waters, Cytiva ÄKTA Avant, Pure purification systems
Responsibilities
Establish pre-clinical oligonucleotide conjugation capabilities, Perform hands-on synthesis of small molecules, lipids, and linkers, Design and implement synthetic routes, Develop and maintain SOPs for synthesis and purification, Serve as SME for small molecule and lipid conjugates, Collaborate with analytical and chemistry teams
Seniority
Principal, hands-on IC with mentorship