Scientist / Senior Scientist, Structural Biology
Core
Develop practical structural biology strategies and deliver high-quality structural insights to support therapeutic program decisions and drug discovery.
Role type
Senior Scientist, Structural Biology (IC)
Builds
Structural analysis data and insights for biologics and small-molecule drug discovery
Domain
Biotechnology / Structural Biology
Deliverable
production ML models | product features | dashboards & analysis | research
Required skills
CryoEM sample preparation, CryoEM data collection, image processing, model building, refinement, structural interpretation, X-ray crystallography, MicroED, electron tomography, integrative structural biology, Python scripting, Glacios/Titan Krios operation
Preferred skills
Structure-based drug discovery experience, membrane protein/antibody/GPCR expertise, methodology development, mentoring, automated data collection software (EPU), scientific publications
Technologies
Glacios, Titan Krios, EPU, Python
Responsibilities
Partner with discovery teams to define structural biology strategies and experimental plans; Perform and guide cryo-sample preparation, grid optimization, screening, data collection, image processing, model building, refinement, and structural interpretation; Develop scalable, reproducible CryoEM workflows; Collaborate across Structural Biology, Protein Sciences, Therapeutic Discovery, Protein Engineering, Computational Biology, Medicinal Chemistry, Automation, Molecular Characterization, and therapeutic area teams; Coordinate activities across internal facilities, external collaborators, and instrument vendors; Evaluate and implement emerging technologies including automation and AI-enabled tools; Support and/or lead CryoEM platform activities at the South San Francisco site; Contribute to scientific innovation through technology development, publications, presentations, and knowledge sharing
Seniority
Senior, hands-on IC
