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Executive Director, AIRx Program Lead: Biologics

Boston, MA💼 Full-time💰 $238,000–$238,000🗓 2026-05-31 → 2026-07-31

Core

Lead end-to-end scientific and strategic direction of 2–3 large molecule discovery programs using AI-enabled protein design and automation to deliver candidates to the clinic.

Role type

Senior IC biologic drug discovery program lead

Builds

Large molecule drug candidates (antibodies, bispecifics, fusion proteins) for clinical development

Domain

Biopharmaceuticals / Large molecule discovery

Deliverable

production ML models | product features

Required skills

Biologic drug discovery strategy, protein engineering (affinity maturation, Fc engineering), AI/ML for protein design, CMC and toxicology oversight, CRO/CDMO management, PK/PD modeling, IND filing

Preferred skills

Experience with phage/yeast display, single B cell selection, subcutaneous absorption strategies, in-licensing evaluation

Technologies

Generative protein design tools, structure-prediction platforms, AI/ML frameworks for biology

Responsibilities

Define and evolve program strategy for large molecule modalities; evaluate and prioritize candidates based on scientific and commercial considerations; lead rapid AI-enabled design and test cycles; manage external CROs and CDMOs; represent Takeda externally for platform technologies and in-licensing; ensure disciplined cost stewardship

Seniority

Senior, hands-on IC with strategic oversight

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