Senior Director, AIRx Biologics Discovery Lead
Core
Lead end-to-end biologics discovery from lead generation to IND filing for 2–3 large molecule programs using AI-enabled protein design and automated platforms.
Role type
Senior Director, Biologics Discovery Lead
Builds
Large molecule discovery programs (antibodies, bispecifics, fusion proteins) to clinic
Domain
Biopharmaceuticals / Biologics Discovery / AI-driven Protein Design
Deliverable
production ML models
Required skills
Biologic drug discovery strategy, AI/ML fluency (generative protein design), protein engineering, CMC considerations, DMPK modeling, CRO/CDMO management, IND filing
Preferred skills
Experience with RFdiffusion, ProteinMPNN, ESMFold, AlphaFold, yeast display, single B cell technology
Technologies
RFdiffusion, ProteinMPNN, ESMFold, AlphaFold
Responsibilities
Drive biologics discovery from target selection to candidate nomination; Integrate AI-driven protein design and high-throughput platforms; Evaluate and prioritize biologic candidates; Lead sequence optimization and affinity maturation; Manage external CRO/CDMO execution; Represent AIRx externally on platform technologies and BD
Seniority
Senior Director, strategic leadership & hands-on science
