Senior/Principal Scientist, Small Molecule Therapeutics
Core
Lead early hit identification efforts using DNA-encoded libraries (DEL) and complementary screening technologies to discover and validate novel chemical matter for small molecule therapeutics.
Role type
Senior/Principal Scientist, Small Molecule Therapeutics
Builds
DNA-encoded library (DEL) screening capabilities integrated with AI-enabled chemistry design and automated synthesis platforms
Domain
Biopharmaceuticals / Small Molecule Drug Discovery
Deliverable
production ML models | product features | dashboards & analysis | research | client delivery | infrastructure | physical/clinical work
Required skills
DNA-encoded library (DEL) screening design and execution, biochemical and biophysical assay development and optimization, protein construct design and evaluation, hit-to-lead workflow management, automation and robotics lab operations, biophysical data interpretation (SPR, BLI, DSF, ITC, MST), cross-functional collaboration
Preferred skills
Large-scale screening approaches, screening data analysis and stewardship, machine learning integration in experimental design, instrumentation evaluation and workflow design
Technologies
SPR, BLI, DSF, ITC, MST, liquid handling systems, robotic synthesis platforms
Responsibilities
Design and execute DEL screening campaigns including selection strategy and data interpretation, develop and optimize biochemical and biophysical assays for hit validation, establish collaborations to secure high-quality protein sources, define and produce optimal protein constructs for screening, evaluate and implement complementary screening modalities, drive progression of hits through assay cascades
Seniority
Senior/Principal, hands-on IC with strategic oversight