Distinguished Scientist, Small MoleculeTherapeutics
Core
Designing and implementing biophysical instrumentation, assay platforms, and DNA-encoded library (DEL) screening workflows to identify and validate novel small molecule therapeutics.
Role type
Distinguished Scientist, Small Molecule Therapeutics (Senior IC)
Builds
Biophysical instrumentation, scalable assay platforms, and DEL screening pipelines for hit confirmation and validation.
Domain
Biotechnology / Small Molecule Drug Discovery / Biophysics
Deliverable
production ML models | product features | dashboards & analysis | research | client delivery | infrastructure | physical/clinical work
Required skills
DNA-encoded library (DEL) screening, biophysical assay development, biochemical activity assays, high-throughput screening (HTS) campaign execution, automation and robotics lab integration, protein construct design and purification, hit triage and validation workflows, medicinal chemistry partnership
Preferred skills
SPR, DSF, BLI, MST, MS-based methods, ITC, fragment-based screening, AI-enabled drug discovery integration, large-scale screening data analysis, building screening capabilities from ground up
Technologies
SPR, DSF, BLI, MST, MS, ITC, liquid handling robots, DNA-encoded libraries
Responsibilities
Implement and scale biophysical instrumentation and assay platforms; Build screening technologies integrated with AI-driven chemistry and robotic synthesis; Establish and optimize biochemical activity assays; Develop mechanistic assays to determine mode of action; Design, produce, and characterize protein constructs; Execute DEL screening strategies and downstream validation pipelines
Seniority
Distinguished, hands-on IC with strategic scope