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Director/Senior Director, Molecular Discovery

Alewife, Cambridge, MA💼 Full-time💰 $202,400–$202,400🗓 2026-06-22 → 2026-07-31

Core

Lead end-to-end small molecule drug discovery programs using an autonomous AI science platform to deliver validated drug candidates for clinical advancement.

Role type

Senior Director, Molecular Discovery (Program Leadership)

Builds

Small molecule drug candidates from hit identification through lead optimization and candidate nomination

Domain

Biotechnology / AI-driven Drug Discovery

Deliverable

production ML models | product features

Required skills

Medicinal chemistry principles, ADMET/DMPK expertise, AI/ML-driven molecular design judgment, program management, cross-functional collaboration, scientific strategy

Preferred skills

Experience with automated high-throughput discovery environments, cheminformatics, scaling discovery operations, multi-therapeutic area background

Technologies

Generative chemistry, molecular property prediction, free energy methods, active learning

Responsibilities

Own small molecule discovery programs against assigned targets, set and hit discovery output timelines and quality benchmarks, act as primary interface between autonomous platform and decision-making, collaborate with AI/ML and engineering teams to improve platform accuracy, architect discovery program components and assay cascades, facilitate relationships with external CROs

Seniority

Senior Director, hands-on IC with program leadership

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