Scientist I, Multi-Specifics Expression
Core
Engineering CHO cell lines and optimizing expression processes for complex multi-specific biologics to support drug discovery.
Role type
Scientist I, multi-specific protein expression (hands-on IC)
Builds
Stable CHO cell lines expressing multi-specific molecules for therapeutic discovery
Domain
Biopharmaceuticals / Protein Engineering / Cell Biology
Deliverable
production ML models | product features | dashboards & analysis | research | client delivery | infrastructure | physical/clinical work
Required skills
CHO cell culture, stable cell line generation, multi-specific protein expression, process optimization, analytical HPLC, ddPCR, FACS, vector design, bioreactor operation
Preferred skills
Experience with Wave bioreactors, troubleshooting aggregation/glycosylation issues, automation platform implementation
Technologies
CHO cells, ddPCR, FACS, HPLC, Wave bioreactors
Responsibilities
Generate and screen stable CHO cell lines with optimized attributes for multi-specific molecules; Optimize chain ratios and expression processes for 3- and 4-chain molecules; Characterize copy number and mRNA transcript levels; Troubleshoot expression challenges like aggregation and glycosylation; Implement automation and high-throughput workflows; Purify and biophysically characterize analytical scale samples.
Seniority
Individual Contributor, early-career scientist (5+ years BS or 2+ years MS)