Senior Scientist I - Cell Culture Process Development
Core
Develop and characterize highly-productive CHO cell culture processes for cGMP biotherapeutic manufacturing, leading R&D initiatives to reduce cost of goods (COGs) through process optimization and technology transfer.
Role type
Senior Scientist I - Cell Culture Process Development
Builds
cGMP biotherapeutics (therapeutic proteins) for AbbVie pipeline
Domain
Biopharmaceuticals / Cell Culture Engineering
Deliverable
production ML models | product features | dashboards & analysis | research | client delivery | infrastructure | physical/clinical work
Required skills
CHO cell culture process development, Design of Experiments (DOE), cell metabolic modeling, perfusion technology, Process Analytical Technology (PAT), mammalian suspension cell culture, bioreactor operation, troubleshooting, data analysis, technical reporting
Preferred skills
Process scale up and scale down, recombinant protein production, protein characterization, mechanistic modeling, machine learning algorithms, bench scale bioreactors (AMBR, shake flasks)
Technologies
AMBR, shake flasks, bioreactors, PAT tools
Responsibilities
Develop and characterize CHO cell culture processes suitable for cGMP manufacturing; Lead and execute scientific research and development initiatives to reduce cost of goods; Design, execute, and analyze cell culture experiments using DOE principles; Work collaboratively with cross-functional teams (Analytical Development, Cell Line Development, Manufacturing, Quality); Author and review technical reports, protocols, and key documents.
Seniority
Senior, hands-on IC