Principal Scientist - Process Development, Upstream
Core
Lead the development and implementation of mammalian cell culture upstream processing methodologies and analytical procedures for transfer to cGMP manufacturing to generate therapeutic proteins.
Role type
Principal Scientist, Process Development (Upstream)
Builds
Therapeutic proteins for clinical trials
Domain
Biopharma / Upstream Process Development
Deliverable
production ML models | product features | dashboards & analysis | research | client delivery | infrastructure | physical/clinical work
Required skills
Mammalian cell culture, Bioreactor operations, Design of Experiments (DoE), Process optimization, Tech transfer, cGMP environment, Technical writing, Data analysis, Project leadership
Preferred skills
None stated
Technologies
None stated
Responsibilities
Lead development of upstream processing methodologies and analytical procedures; Troubleshoot and problem solve process issues; Design and execute process development experiments including seed train scale-up; Apply Design of Experiments (DoE) for clone screening and process optimization; Support tech transfer activities to manufacturing; Lead multiple complex projects as a technical lead; Analyze and interpret complex data to provide insights
Seniority
Principal, hands-on IC with technical leadership
