Senior Scientist, siRNA Analytical Development
Core
Develop, optimize, and execute analytical methods for the characterization of siRNA and oligonucleotide therapeutics to ensure high-quality materials for genetic medicine programs.
Role type
Senior Scientist, siRNA Analytical Development
Builds
Well-characterized siRNA and oligonucleotide materials for genetic medicine programs
Domain
Biotechnology / Pharmaceutical / RNA-based therapeutics
Deliverable
production ML models | product features | dashboards & analysis | research | client delivery | infrastructure | physical/clinical work
Required skills
HPLC techniques (RP-HPLC, IEX, IP-RP), LC-MS, UV spectroscopy, RNA chemistry, oligonucleotide modifications, conjugation chemistry, data analysis software, method development, impurity profiling, data integrity
Preferred skills
Troubleshooting complex analytical problems, continuous method improvement, presenting scientific data
Technologies
HPLC, IEX-HPLC, IP-RP-HPLC, LC-MS, UV/fluorescence spectroscopy
Responsibilities
Develop and optimize analytical methods for siRNA and oligonucleotide characterization; Perform purity assessment, identity confirmation, quantification, and impurity profiling; Develop analytical strategies for novel siRNA modifications and conjugates; Generate, review, and interpret analytical data with rigor; Maintain laboratory documentation including experimental records and SOPs; Partner with cross-functional teams including synthesis, antibody conjugation, and CMC
Seniority
Senior, hands-on IC