Scientist, Analytical Sciences
Core
Develop and implement analytical technologies for impurity characterization of siRNA therapeutics using liquid chromatography and mass spectrometry.
Role type
Scientist, Analytical Sciences (siRNA impurity characterization)
Builds
HPLC-based assays for mass and structural identification of siRNA therapeutics and formulations
Domain
Biopharmaceuticals / RNAi therapeutics / Analytical Chemistry
Deliverable
production ML models | product features | dashboards & analysis | research | client delivery | infrastructure | physical/clinical work
Required skills
UHPLC method development, high-resolution mass spectrometry, design of experiments, oligonucleotide LC-assay qualification, multidimensional LC-MS, hardware/software troubleshooting, regulatory documentation
Preferred skills
Oligonucleotide LC-assay transfer, automation workflow implementation, cross-functional program representation
Technologies
Waters Empower, Masslynx, UNIFI, Agilent Openlab, Masshunter
Responsibilities
Develop, qualify, scale up, and transfer HPLC assays for impurity determination; support forced degradation studies; implement novel workflows to increase operational efficiency; author development reports and regulatory filing documents; troubleshoot LC-MS hardware and software; represent analytical sciences in cross-functional early stage development
Seniority
Mid-level Scientist (2+ years experience)
