Principal Research Scientist I, siRNA Synthesis & Analytical Development
Core
Lead the siRNA synthesis platform to support genetic medicine studies by establishing synthesis, purification, and analytical capabilities.
Role type
Principal Research Scientist (siRNA Synthesis & Analytical Development)
Builds
High-quality siRNA materials for genetic medicine studies
Domain
Biotechnology / Pharma / Oligonucleotide Chemistry
Deliverable
production ML models | product features | dashboards & analysis | research | client delivery | infrastructure | physical/clinical work
Required skills
siRNA synthesis, purification, and characterization; oligonucleotide chemistry; RNA chemistry; conjugation chemistry; HPLC; LC-MS; UV spectroscopy; complex technical problem solving; people management
Preferred skills
Prior people management experience
Technologies
solid-phase synthesis; deprotection; desalting
Responsibilities
Lead the siRNA synthesis platform; oversee solid-phase oligonucleotide synthesis, deprotection, purification, desalting, and analytical characterization; troubleshoot synthesis, purification, and analytical challenges to improve yield, purity, and scalability; partner with cross-functional teams including siRNA screening, antibody conjugation, and CMC; ensure rigorous documentation, data integrity, and compliance; track and evaluate emerging technologies in oligonucleotide and RNA-based therapeutics; manage and develop a team of 2–3 scientists
Seniority
Principal, hands-on IC with mentorship