Principal Research Scientist I, siRNA Platform Automation
Core
Establish and implement a high-throughput siRNA screening platform using automated liquid-handling systems to advance pipeline innovation and support the discovery of therapeutic leads.
Role type
Principal Research Scientist (siRNA Platform Automation)
Builds
High-throughput siRNA screening platforms and optimized siRNA sequences
Domain
Biotechnology / Pharma / siRNA therapeutics
Deliverable
production ML models | product features | dashboards & analysis | research | client delivery | infrastructure | physical/clinical work
Required skills
siRNA design, in vitro screening, potency assays, automated high-throughput platforms, qRT-PCR, ELISA, flow cytometry, cell culture, team leadership
Preferred skills
animal study design, downstream assays for genetic medicines, prior people management experience
Technologies
Hamilton, Tecan
Responsibilities
Establish and implement a high-throughput siRNA screening platform using automated liquid-handling systems; Serve as a subject matter expert in siRNA screening experimental design, execution, and data interpretation; Lead research efforts and mentor scientists to advance siRNA optimization; Generate new scientific hypotheses and proposals, improve existing screening workflows, and evaluate emerging technologies; Manage and develop a team of at least 2-3 scientists, providing technical guidance, mentorship, and day-to-day leadership
Seniority
Principal, hands-on IC with mentorship