Principal Associate Scientist, Target Validation
Core
Validate therapeutic gene targets through in vitro and in vivo mechanistic studies to support discovery efforts for future RNAi medicines.
Role type
Principal Associate Scientist (Target Validation)
Builds
RNAi compounds for novel indications
Domain
Biotechnology / RNAi therapeutics
Deliverable
production ML models | product features | dashboards & analysis | research | client delivery | infrastructure | physical/clinical work
Required skills
in vivo rodent studies, RNA extraction, mammalian cell culture, molecular biology assays (qPCR, Western blotting, ELISA, immunoprecipitations), quantitative data analysis, GraphPad Prism, Excel, statistical methods, laboratory notebook documentation
Preferred skills
muscle/cardiovascular/endocrine disease biology, preclinical models
Technologies
GraphPad Prism, Excel
Responsibilities
Engage in investigative, mechanistic target validation and proof-of-concept preclinical research; Perform in vivo proof-of-concept studies to evaluate novel siRNA delivery platforms; Develop, optimize, and validate new assays to support emerging targets and biomarker development; Contribute to internal decision-making by integrating knockdown data with orthogonal readouts; Prepare experimental reports and data presentations; Maintain detailed laboratory notebooks and electronic data records
Seniority
Senior, hands-on IC