Research Fellow, Chemical Biology & Proteomics
Core
Develop and apply chemoproteomic methods to profile covalent inhibitors in live cells, characterize proteome-wide selectivity, and identify ligandable proteins for drug discovery.
Role type
Research Fellow, Chemical Biology & Proteomics
Builds
Chemoproteomic platforms and data for drug discovery programs
Domain
Chemical Biology / Proteomics / Drug Discovery
Deliverable
production ML models | product features | dashboards & analysis | research | client delivery | infrastructure | physical/clinical work
Required skills
covalent ligand discovery, bioorthogonal chemistry, mammalian cell culture, LC-MS/MS sample preparation, quantitative proteomics workflows, protein biochemistry, target engagement assays, mechanism-of-action studies
Preferred skills
ABPP, isoTOP-ABPP, cysteinome profiling, TMT/DIA/PRM quantitative proteomics, FragPipe/MaxQuant/DIA-NN data analysis, covalent inhibitor design, affinity enrichment strategies
Technologies
LC-MS/MS, bioorthogonal click chemistry, TMT, DIA, PRM, FragPipe, MaxQuant, DIA-NN
Responsibilities
Design and execute chemoproteomic experiments to characterize target engagement and selectivity; Perform live-cell labeling and enrichment workflows; Optimize workflows for profiling reactive amino acid residues; Conduct mammalian cell culture and prepare samples for LC-MS/MS; Analyze large-scale proteomic datasets to identify protein interactions; Collaborate with medicinal chemistry and biology teams to guide compound optimization; Evaluate emerging technologies and implement new methodologies; Present research findings at meetings and conferences
Seniority
Professional, hands-on IC