Discovery Postdoctoral Fellow – Inflammatory Bowel Disease Research
Core
Develop and apply human organoid and cellular models to investigate mechanisms regulating intestinal tissue function and inflammation in Inflammatory Bowel Disease (IBD) to identify novel therapeutic targets.
Role type
Postdoctoral Research Fellow (Cell Biology/Molecular Biology)
Builds
Human-derived experimental systems (organoids, cellular models) for target discovery and translational research
Domain
Biomedical research / Drug discovery / Inflammatory Bowel Disease
Deliverable
production ML models | product features | dashboards & analysis | research | client delivery | infrastructure | physical/clinical work
Required skills
Complex mammalian cell culture (organoids, stem-cell-derived models), Molecular and cellular biology, Genetic perturbation (CRISPR-Cas9), Functional screening, Data interpretation, Experimental design
Preferred skills
CRISPR-based genome engineering, Developing functional assays in complex intestinal models
Technologies
CRISPR-Cas9, Multi-omics platforms, Single-cell omics
Responsibilities
Establish human intestinal organoid and epithelial barrier models for IBD research, Develop assays assessing barrier integrity, inflammatory responses, and multi-omics profiles, Implement CRISPR-Cas9 genetic perturbations in organoid systems, Execute medium-throughput functional screening of IBD-associated genetic risk factors, Identify and prioritize novel therapeutic targets based on genetic risk factors and functional screening data, Drive experimental design, data interpretation, and project advancement
Seniority
Postdoctoral Fellow (Early-career scientist immediately following PhD)
