Scientist, Advanced Cell Models & Delivery Biology
Core
Develop and apply advanced in vitro cellular models to support the discovery and optimization of novel delivery strategies for RNAi therapeutics.
Role type
Scientist, Advanced Cell Models & Delivery Biology
Builds
In vitro cellular models for RNAi therapeutic delivery evaluation
Domain
Biotechnology / RNAi therapeutics / Cell biology
Deliverable
production ML models | product features | dashboards & analysis | research | client delivery | infrastructure | physical/clinical work
Required skills
Advanced in vitro cellular systems (primary cells, organoids, spheroids, co-cultures, microphysiological systems), cell-based assay development, receptor biology, cellular uptake mechanisms, ligand-receptor interactions, imaging technologies, protein-based characterization methods, experimental design, data interpretation
Preferred skills
Oligonucleotide therapeutics experience, RNAi, ASOs, peptides, antibodies, targeted delivery technologies
Technologies
Imaging-based technologies, protein-based assays, molecular biology techniques
Responsibilities
Establish and optimize advanced 2D and 3D cellular models including primary cell systems and organoids; Design and execute studies to evaluate receptor-mediated delivery and cellular uptake; Identify gaps in existing model capabilities and develop novel cellular systems; Utilize imaging and protein-based assays to characterize receptor expression and uptake mechanisms; Generate mechanistic insights to support ligand selection and delivery optimization; Evaluate the predictive value and translational relevance of in vitro models
Seniority
Early-career Scientist (0-3 years industry/post-doc experience)