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Senior Scientist, Protein and Antibody Bioconjugation

US CA San Diego💼 Full-time💰 $110,800–$110,800🗓 2026-05-29 → 2026-07-31

Core

Design, synthesize, and characterize novel bioconjugate modalities including antibody-peptide, antibody-oligonucleotide, and antibody-drug conjugates to advance therapeutic pipelines.

Role type

Senior Scientist, Protein and Antibody Bioconjugation

Builds

Novel bioconjugate modalities (APC, AOC, ADC) for neurological, psychiatric, endocrine, and immunological disorders

Domain

Biopharmaceuticals / Protein Chemistry / Bioconjugation

Deliverable

production ML models | product features | dashboards & analysis | research | client delivery | infrastructure | physical/clinical work

Required skills

protein bioconjugation, antibody conjugates, purification techniques, analytical characterization, RP-HPLC, LC-MS, site-specific conjugation, structure-activity relationships (SAR)

Preferred skills

stochastic vs site-specific conjugation strategies, formulation strategies, peptide/siRNA/protein structure knowledge, biophysical techniques

Technologies

RP-HPLC, LC-MS, FPLC-AKTA, size-exclusion (SEC), ion exchange (IEX), tangential flow filtration (TFF)

Responsibilities

Design and synthesize antibody conjugates using state-of-the-art bioconjugation methods; optimize conjugation protocols for various modalities; troubleshoot critical issues in conjugation processes; collaborate cross-functionally to design linker-payload biologic SAR; maintain accurate lab notebooks and batch records for regulatory compliance

Seniority

Senior, hands-on IC

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