Scientist, R&D Chemistry, Peptidomimetic Synthesis
Core
Synthesize and optimize peptidomimetic and linker payloads for antibody-conjugate drug therapeutics using modern peptide synthesis and medicinal chemistry strategies.
Role type
Senior IC synthetic organic/medicinal chemist (peptidomimetics)
Builds
Novel peptidomimetic drug modality payloads and linker payloads for antibody conjugates
Domain
Biopharmaceuticals / Chemical Biology / Drug Discovery
Deliverable
production ML models | product features | dashboards & analysis | research | client delivery | infrastructure | physical/clinical work
Required skills
Peptidomimetic synthesis, SAR optimization, non-natural amino acid incorporation, alpha-Me/N-Me peptide backbone modifications, small molecule synthesis, drug discovery, bioconjugation, modern peptide synthesis techniques, analytical characterization, reaction troubleshooting
Preferred skills
Master's degree in peptide/peptidomimetic or synthetic organic chemistry, experience with modern synthesis/isolation/characterization instrumentation
Technologies
Modern peptide synthesizer, isolation equipment, characterization instrumentation
Responsibilities
Perform SAR-driven synthesis of novel peptidomimetic drug modality payloads/linker payloads, troubleshoot and optimize peptide potency and stability, identify new strategies to improve existing platforms, participate in cross-functional project teams, represent group vision in meetings
Seniority
Senior, hands-on IC