R&D - Intrepide - Principal Scientist I, Antibody Engineering - SZ
Core
Lead and execute the engineering of therapeutic antibody candidates using classical methods and AI/ML-based tools to optimize properties like affinity, stability, and developability.
Role type
Principal Scientist I, Antibody Engineering (hands-on IC)
Builds
Therapeutic antibody candidates for biologics research
Domain
Biopharmaceuticals / Protein Engineering / AI for Science
Deliverable
production ML models | product features
Required skills
Antibody engineering (liability removal, humanization, affinity maturation), Biophysical profiling (DSF, DLS, SEC, viscosity), Directed evolution (phage/yeast display), Structure-based generative AI (ProteinMPNN, RFdiffusion, AlphaFold), Python scripting
Preferred skills
CDR grafting, Back-mutation analysis, Fine-tuning pre-trained models on antibody datasets, Experience with mammalian transient expression
Technologies
ProteinMPNN, RFdiffusion, ESMFold, AlphaFold2/3, Rosetta/PyRosetta, AbMPNN
Responsibilities
Execute liability engineering to resolve deamidation, oxidation, and aggregation hotspots; Lead affinity maturation campaigns using directed evolution; Drive developability optimization through biophysical profiling; Translate computational sequence proposals into wet-lab validation experiments; Mentor junior scientists on technical guidance and career development
Seniority
Principal, hands-on IC with mentorship
