Principal Scientist, Antibody Discovery and Engineering
Core
Lead integrated antibody discovery and engineering campaigns from early concept through lead identification, optimization, and nomination for oncology and autoimmune disease programs.
Role type
Principal Scientist, Antibody Discovery and Engineering
Builds
Novel antibody-based therapeutic molecules (IgG, bispecifics, T cell engagers, etc.) for First-in-Human studies
Domain
Biopharmaceuticals / Immunology / Oncology / Autoimmune
Deliverable
production ML models | product features | dashboards & analysis | research | client delivery | infrastructure | physical/clinical work
Required skills
therapeutic antibody discovery, antibody engineering, immune repertoire mining, display technologies, molecular-format optimization, immunization design, B cell screening, sequence analysis, affinity maturation, humanization, format conversion, expression, purification, characterization, functional cell-based assay design, CRO management
Preferred skills
yeast or mammalian display technologies, advanced therapeutic formats (ADCs, CAR-T), immune-cell biology, bioinformatics, structural modeling, AI/ML-enabled discovery tools, mentoring
Technologies
Biacore, Carterra, Octet, ELISA, MSD, multi-parameter flow cytometry, NGS
Responsibilities
Lead discovery campaigns from concept to lead nomination; develop discovery strategies incorporating target/antigen evaluation and data-driven selection; design and oversee antibody generation workflows; engineer and evaluate antibodies across multiple formats; characterize candidates using biochemical, biophysical, and functional assays; partner with cross-functional teams to move programs to actionable leads; analyze complex datasets and mitigate technical risks; prepare technical reports and presentations; mentor scientists and manage external partners
Seniority
Principal, hands-on scientific leadership with strategy & mentorship
