Principal Scientist, Antibody Discovery and Engineering
Core
Lead integrated antibody discovery and engineering campaigns from early concept through lead identification, optimization, and nomination for oncology and autoimmune disease programs.
Role type
Principal Scientist, hands-on scientific leadership
Builds
Novel antibody-based therapeutic molecules (IgG, bispecifics, T cell engagers, etc.) for First-in-Human studies
Domain
Biopharmaceuticals / Immunology / Antibody Engineering
Required skills
therapeutic antibody discovery, antibody engineering, immune repertoire mining, display technologies, molecular-format optimization, immunization design, B cell screening, sequence analysis, affinity maturation, humanization, expression/purification, biochemical/biophysical characterization, functional cell-based assays, CRO management
Preferred skills
yeast/mammalian display technologies, advanced therapeutic formats (ADCs, CAR-T), immune-cell biology, bioinformatics/structural modeling/AI tools, mentoring
Technologies
Biacore, Carterra, Octet, ELISA, MSD, multi-parameter flow cytometry, NGS
Responsibilities
Lead discovery campaigns from concept to lead nomination; Design discovery strategies incorporating target/antigen evaluation and immunization; Execute antibody generation workflows (immunization, display, affinity maturation); Engineer and evaluate antibodies across multiple formats; Characterize candidates using biochemical, biophysical, and functional assays; Partner with antigen design, structural/computational biology, and project teams; Analyze complex datasets to identify risks and guide decisions; Monitor emerging technologies and translate advances into capabilities; Prepare technical reports and presentations; Lead cross-functional discussions and mentor scientists
Seniority
Principal, hands-on scientific leadership
