Senior Scientist / Associate Director, T Cell Immunology
Core
Lead T cell immunology strategy and execution for in vivo cell therapy programs in oncology and autoimmunity, from primary human cell assays through IND-enabling studies.
Role type
Senior IC scientist / Associate Director (T cell immunology)
Builds
In vivo cell therapies (gene-edited T cells) for oncology and autoimmunity
Domain
Biotechnology / Cell and Gene Therapy / Immunology
Required skills
Primary human T cell biology, Gene editing in immune cells, Multiparameter flow cytometry, ddPCR/qPCR/NGS, In vivo mouse study design, IND-enabling study design
Preferred skills
NHP study design, Regulatory filing experience (pharmacology/toxicology), Regulatory landscape knowledge for genome-edited therapies
Technologies
Flow cytometry, ddPCR, qPCR, NGS
Responsibilities
Own T cell immunology strategy and assay/study plans; Lead translation into in vivo models (mouse/NHP); Drive pharmacology and safety components of IND-enabling work; Represent data in pre-IND and agency interactions; Design and run in vitro potency/specificity assays; Mentor scientists and grow the team